Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction
نویسندگان
چکیده
منابع مشابه
Weighted Risk Score-Based Multifactor Dimensionality Reduction to Detect Gene-Gene Interactions in Nasopharyngeal Carcinoma
Determining the complex relationships between diseases, polymorphisms in human genes and environmental factors is challenging. Multifactor dimensionality reduction (MDR) has been proven to be capable of effectively detecting the statistical patterns of epistasis, although classification accuracy is required for this approach. The imbalanced dataset can cause seriously negative effects on classi...
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MOTIVATION The identification and characterization of susceptibility genes that influence the risk of common and complex diseases remains a statistical and computational challenge in genetic association studies. This is partly because the effect of any single genetic variant for a common and complex disease may be dependent on other genetic variants (gene-gene interaction) and environmental fac...
متن کاملPair-wise multifactor dimensionality reduction method to detect gene-gene interactions in a case-control study.
OBJECTIVE The identification of gene-gene interactions has been limited by small sample size and large number of potential interactions between genes. To address this issue, Ritchie et al. [2001] have proposed multifactor dimensionality reduction (MDR) method to detect polymorphisms associated with the disease risk. The MDR reduces the dimension of the genetic factors by classifying them into h...
متن کاملMultifactor dimensionality reduction for detecting gene-gene and gene-environment interactions in pharmacogenomics studies.
In the quest for discovering disease susceptibility genes, the reality of gene-gene and gene-environment interactions creates difficult challenges for many current statistical approaches. In an attempt to overcome limitations with current disease gene detection methods, the multifactor dimensionality reduction (MDR) approach was previously developed. In brief, MDR is a method that reduces the d...
متن کاملMultifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions
MOTIVATION Polymorphisms in human genes are being described in remarkable numbers. Determining which polymorphisms and which environmental factors are associated with common, complex diseases has become a daunting task. This is partly because the effect of any single genetic variation will likely be dependent on other genetic variations (gene-gene interaction or epistasis) and environmental fac...
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ژورنال
عنوان ژورنال: BioData Mining
سال: 2013
ISSN: 1756-0381
DOI: 10.1186/1756-0381-6-1